| 英文別名： |
1-Methyl-1H-imidazole-2(3H)-thione;TAPAZOLE;THIAMAZOLE;1,3-dihydro-1-methyl-2h-imidazole-2-thion;1,3-dihydro-1-methyl-2H-Imidazole-2-thione;1-methyl-2-mercapto-imidazol;1-methyl-imidazole-2-thio;1-Metylo 2 merkaptoimidazolem;2-Mercapto-1-methylimidazole;1-Methylimidazole-2-thiol;Methimazole;1,3-Dihydro-1-Methyl-2H-iMidazole-2-thione;1-methyl-1H-imidazole-2-thiol;1-methyl-2-mercapto-imidazole;1-Methyl-2-MercaptoiMidazole;2-mercapto-1-methyl-imidazole;Basolan;Favistan;Frentirox;Mecazolyl;mercaptomethylimidazole;Mercazole;Merkastan;METAZOLE;Metazolo;Metizol;Tapuzole;thioimidazole;1,3-dihydro-1-methyl-2H-Imidazole-2-thione 1-methyl-imidazole-2-thio;Mercazolyl;Thymidazole;Methimazol;Thymidazol;Thiamazol;Thycapzol;Metothyrine;Metothyrin;Merkazolil;Mercaptazole;Strumazol;Thycapsol;Metotirin;Danantizol;Thacapzol;Tiamazol;Mercasolyl;Methylmercaptoimidazole;Methiamazole;Methimazolum;Mercazolylum;Metimazol;Thiama;HMS2090B17;H10722;NSC 38608;Henning Berlin Brand of Methimazole;AMY11202;Methimazole [USAN:BAN];2-mercapto-3-methylimidazole;Thiamazole (JP17/INN);AB00443630_07;BPBio1_000982;BS-3743;KBio2_004043;1-methyl-1-H-imidazole-2-thiol;NCGC00016273-03;Methimazole-d3(methyl-d3);Prestwick2_000786;Imidazole, 1-methyl-2-mercapto-;Thyrozol;NCGC00094721-07;Methimazole (Tapazole, Northyx);NCGC00254307-01;1-Methyl-2-Imidazolethione;Methimazole, VETRANAL(TM), analytical standard;METHIMAZOLE [USP-RS];2-mecapto 1-methylimidazole;Spectrum5_000954;HMS3259L09;Methamazole;Tox21_201341;Sanofi Synthelabo Brand of Methimazole;THIAMAZOLE (EP MONOGRAPH);D0S4BR;HMS3714M14;M0868;Imidazole-2-thio, 1-methyl-;Tapazole (TN);A832780;1-Methyl-2-imidazolethiol;Thiamazole,(S);HMS2097M14;Prestwick_1010;LS-7490;F1679-0258;NCGC00094721-05;NSC-38608;Temmler Brand of Methimazole;IDI1_000188;KBio1_000188;2-mercapto-N-methylimidazole;1-methylimidazole-2-thione;THIAMAZOLE [EP MONOGRAPH];Mercaptizole;CCG-220786;NCGC00016273-01;Methimazole, analytical standard;AC-785;DTXSID4020820;BSPBio_001989;HSDB 3361;THIAMAZOLE [WHO-DD];THIAMAZOLE (MART.);SR-05000001672;METHIMAZOLE (USP-RS);Tox21_300532;CCG-39656;Tiamazolo [DCIT];MLS002548853;FT-0603253;SR-05000001672-2;SPBio_002831;Tox21_110341_1;N-Methyl-2-mercaptoimidazole;NCGC00016273-02;Q-201364;Spectrum_000995;STK802184;Methimazole (USP);Thiamazol Hexal;SPBio_001266;SMR000058376;1-methyl-2,3-dihydro-1H-imidazole-2-thione;4-Imidazoline-2-thione, 1-methyl-;Spectrum4_000048;DTXCID20820;METHIMAZOLE (USP MONOGRAPH);SR-05000001672-1;BSPBio_000892;DivK1c_000188;GTPL6649;HMS2094C05;F0001-2396;H03BB02;DB00763;2H-Imidazol-2-tiona, 1,3-dihidro-1-metil-;Henning, Thiamazol;NCGC00094721-02;METHIMAZOLE [MI];Jones Brand of Methimazole;Thiamazol Henning;Thimazol;Methimazole [USP];Prestwick0_000786;1-Methyl-2-mercapto imidazole;NCGC00094721-04;Tiamazolo;1-methyl-3H-imidazole-2-thione;1-methyl-1H-immidazole-2-thiol;SPECTRUM1500396;Prestwick1_000786;T... |
| 詳細描述： |
甲巰咪唑為抗甲狀腺藥物。其作用機制是抑制甲狀腺內(nèi)過氧化物酶，從而阻礙吸聚到甲狀腺內(nèi)碘化物的氧化及酪氨酸的偶聯(lián)，阻礙甲狀腺素（T4）和三碘甲狀腺原氨酸（T3）的合成。動物實驗觀察到可抑制B淋巴細胞合成抗體，降低血循環(huán)中甲狀腺刺激性抗體的水平，使抑制性T細胞功能恢復正常。 甲巰咪唑抗甲狀腺藥物綜述：抗甲狀腺藥物抑制甲狀腺激素的合成，其作用機制是抑制甲狀腺內(nèi)過氧化物酶，從而阻礙吸聚到甲狀腺內(nèi)碘化物的氧化及酪氨酸的偶聯(lián)，阻礙甲狀腺素(T4)和三碘甲狀腺原氨酸(T3)的合成。另外，丙硫氧嘧啶在外周組織中抑制T4轉(zhuǎn)變?yōu)門3。硫脲類抗甲狀腺藥除阻礙甲狀腺激素合成外，還有輕度的免疫抑制作用?？梢种艬淋巴細胞合成抗體，降低血循環(huán)中甲狀腺刺激性抗體的水平，使抑制性T細胞功能恢復正常。這些作用可能是促使Graves病中免疫紊亂得到緩解的原因。
中文名稱:甲巰咪唑
中文別名:甲巰咪唑/他巴唑/2-巰基-1-甲基咪唑;它巴唑;甲巰咪唑D3;甲巰咪唑,1-甲基咪唑-2-硫醇,甲硫咪唑;甲巰咪唑/甲硫噻唑;甲巰咪唑/他巴唑;1-甲基-2-巰基咪唑;他巴唑(甲巰基咪唑)
英文名稱:Methimazole
英文別名:1-methyl-2-mercapto-imidazol;1-methyl-imidazole-2-thio;1-Metylo2merkaptoimidazolem;1-metylo2merkaptoimidazolem;LABOTEST-BBLT00033517;METHIAZOLE;METHIMAZOL;METHIMAZOLE
CAS號:60-56-0
分子式:C4H6N2S
分子量:114.17 |
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